Unknown

Dataset Information

0

Siderophore-inspired chelator hijacks uranium from aqueous medium.


ABSTRACT: Over millennia, nature has evolved an ability to selectively recognize and sequester specific metal ions by employing a wide variety of supramolecular chelators. Iron-specific molecular carriers-siderophores-are noteworthy for their structural elegance, while exhibiting some of the strongest and most selective binding towards a specific metal ion. Development of simple uranyl (UO22+) recognition motifs possessing siderophore-like selectivity, however, presents a challenge. Herein we report a comprehensive theoretical, crystallographic and spectroscopic studies on the UO22+ binding with a non-toxic siderophore-inspired chelator, 2,6-bis[hydroxy(methyl)amino]-4-morpholino-1,3,5-triazine (H2BHT). The optimal pKa values and structural preorganization endow H2BHT with one of the highest uranyl binding affinity and selectivity among molecular chelators. The results of small-molecule standards are validated by a proof-of-principle development of the H2BHT-functionalized polymeric adsorbent material that affords high uranium uptake capacity even in the presence of competing vanadium (V) ions in aqueous medium.

SUBMITTER: Ivanov AS 

PROVIDER: S-EPMC6379418 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications


Over millennia, nature has evolved an ability to selectively recognize and sequester specific metal ions by employing a wide variety of supramolecular chelators. Iron-specific molecular carriers-siderophores-are noteworthy for their structural elegance, while exhibiting some of the strongest and most selective binding towards a specific metal ion. Development of simple uranyl (UO<sub>2</sub><sup>2+</sup>) recognition motifs possessing siderophore-like selectivity, however, presents a challenge.  ...[more]

Similar Datasets

| S-EPMC6030331 | biostudies-literature
| S-EPMC6880838 | biostudies-literature
| S-EPMC6345739 | biostudies-literature
| S-EPMC5705741 | biostudies-literature
| S-EPMC5920007 | biostudies-literature
| S-EPMC9057722 | biostudies-literature
| S-EPMC5915388 | biostudies-literature
| S-EPMC9289091 | biostudies-literature
| S-EPMC7770698 | biostudies-literature
| S-EPMC4178613 | biostudies-literature