Ontology highlight
ABSTRACT:
SUBMITTER: Fekete A
PROVIDER: S-EPMC6379440 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Fekete Adam A Nakamura Yukihiro Y Yang Yi-Mei YM Herlitze Stefan S Mark Melanie D MD DiGregorio David A DA Wang Lu-Yang LY
Nature communications 20190218 1
Synaptic heterogeneity is widely observed but its underpinnings remain elusive. We addressed this issue using mature calyx of Held synapses whose numbers of bouton-like swellings on stalks of the nerve terminals inversely correlate with release probability (Pr). We examined presynaptic Ca<sup>2+</sup> currents and transients, topology of fluorescently tagged knock-in Ca<sup>2+</sup> channels, and Ca<sup>2+</sup> channel-synaptic vesicle (SV) coupling distance using Ca<sup>2+</sup> chelator and i ...[more]