Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6379485 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Wang Yanfei Y Liu Chi-Hsiu CH Ji Tianjiao T Mehta Manisha M Wang Weiping W Marino Elizabeth E Chen Jing J Kohane Daniel S DS
Nature communications 20190218 1
Choroidal neovascularization (CNV) is the major cause of vision loss in wet age-related macular degeneration (AMD). Current therapies require repeated intravitreal injections, which are painful and can cause infection, bleeding, and retinal detachment. Here we develop nanoparticles (NP-[CPP]) that can be administered intravenously and allow local drug delivery to the diseased choroid via light-triggered targeting. NP-[CPP] is formed by PEG-PLA chains modified with a cell penetrating peptide (CPP ...[more]