Ontology highlight
ABSTRACT:
SUBMITTER: Pang PT
PROVIDER: S-EPMC6380376 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Pang Petti T PT Nagappan Guhan G Guo Wei W Lu Bai B
NPJ science of learning 20160511
Although late-phase long-term potentiation (L-LTP) is implicated in long-term memory, its molecular mechanisms are largely unknown. Here we provide evidence that L-LTP can be divided into two stages: an induction stage (I) and a maintenance stage (II). Both stages require mature brain-derived neurotrophic factor (mBDNF), but involve distinct underlying mechanisms. Stage I requires secretion of existing proBDNF followed by extracellular cleavage by tPA/plasmin. Stage II depends on newly synthesiz ...[more]