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Ion channels as therapeutic antibody targets.

ABSTRACT: It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may facilitate the discovery of antibody therapeutics to ion channels. Additionally, we discuss the potential targeting opportunities in the anti-ion channel antibody landscape, along with a number of case studies where functional antibodies that target ion channels have been reported. Antibodies currently in development and progressing towards the clinic are highlighted.

SUBMITTER: Hutchings CJ

PROVIDER: S-EPMC6380435 | biostudies-literature | 2019 Feb/Mar

REPOSITORIES: biostudies-literature

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Ion channels as therapeutic antibody targets.

Hutchings Catherine J CJ Colussi Paul P Clark Theodore G TG

mAbs 20181210 2

It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may facilitate the discovery of antibody therapeutics to ion channels. Additionally, we discuss the potential targeting opportunities in the anti-ion channel antibody landscape, along with a number of case studies where functional antibodies that target io ...[more]

PMID: 30526315

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