Ontology highlight
ABSTRACT:
SUBMITTER: Kang M
PROVIDER: S-EPMC6380511 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Macromolecules 20160126 3
While a great diversity of peptide-based supra-molecular filaments have been reported, the impact of an auxiliary segment on the chiral assembly of peptides remains poorly understood. Herein we report on the formation of chiral filaments by the self-assembly of a peptide-drug conjugate containing an aromatic drug camptothecin (CPT) in a computational study. We find that the chirality of the filament is mediated by the <i>π</i>‒<i>π</i> stacking between CPTs, not only by the well-expected intermo ...[more]