Dataset Information

Toward 7T breast MRI clinical study: safety assessment using simulation of heterogeneous breast models in RF exposure.

ABSTRACT: PURPOSE:To facilitate assessment of RF power deposition and temperature rise within the breast, we present a method to seamlessly join heterogeneous breast models with standard whole-body models and demonstrate simulations at 7 T. METHODS:Finite-difference time-domain electromagnetic and bioheat simulations are performed to analyze the specific absorption rate (SAR) and temperature rise distributions in 36 Breast Imaging Reporting and Data System (BI-RADS) categorized breast models fused to 2 female whole-body models while transmitting from a 7T breast volume coil. The breast models are uncompressed in the prone position and feature heterogeneous tissue contents; fusion with human models uses affine transformation and the level-set method. RESULTS:The fusion method produces a continuous transient from the chest region to the posterior portion of breast models while preserving the original volume and shape of breast models. Simulation results of both Ella and Hanako models indicate that the maximum local SAR, partial body SAR, and local tissue temperature rise are positively correlated with both breast density and the highest BI-RADS density classification. Additionally, maximum local tissue temperature rise is positively correlated with maximum 10-g SAR values. CONCLUSION:Fibroglandular tissue content plays an important role in the distribution of SAR and temperature rise within breast tissue. The combined body-breast models preserve the integrity of breast models while concurrently exhibiting the loading of whole-body human models. The procedures presented in this simulation study facilitate safety assessments for breast MRI across the population at both clinical and ultrahigh field strengths.

SUBMITTER: Li X

PROVIDER: S-EPMC6380517 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Toward 7T breast MRI clinical study: safety assessment using simulation of heterogeneous breast models in RF exposure.

Li Xin X Rispoli Joseph V JV

Magnetic resonance in medicine 20180914 2

<h4>Purpose</h4>To facilitate assessment of RF power deposition and temperature rise within the breast, we present a method to seamlessly join heterogeneous breast models with standard whole-body models and demonstrate simulations at 7 T.<h4>Methods</h4>Finite-difference time-domain electromagnetic and bioheat simulations are performed to analyze the specific absorption rate (SAR) and temperature rise distributions in 36 Breast Imaging Reporting and Data System (BI-RADS) categorized breast model ...[more]

PMID: 30216530

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Project description:Human voxel models incorporating detailed anatomical features are vital tools for the computational evaluation of electromagnetic (EM) fields within the body. Besides whole-body human voxel models, phantoms representing smaller heterogeneous anatomical features are often employed; for example, localized breast voxel models incorporating fatty and fibroglandular tissues have been developed for a variety of EM applications including mammography simulation and dosimetry, magnetic resonance imaging (MRI), and ultra-wideband microwave imaging. However, considering wavelength effects, electromagnetic modeling of the breast at sub-microwave frequencies necessitates detailed breast phantoms in conjunction with whole-body voxel models.Heterogeneous breast phantoms are sized to fit within radiofrequency coil hardware, modified by voxel-wise extrusion, and fused to whole-body models using voxel-wise, tissue-dependent logical operators. To illustrate the utility of this method, finite-difference time-domain simulations are performed using a whole-body model integrated with a variety of available breast phantoms spanning the standard four tissue density classifications representing the majority of the population.The software library uses a combination of voxel operations to seamlessly size, modify, and fuse eleven breast phantoms to whole-body voxel models. The software is publicly available on GitHub and is linked to the file exchange at MATLAB® Central. Simulations confirm the proportions of fatty and fibroglandular tissues in breast phantoms have significant yet predictable implications on projected power deposition in tissue.Breast phantoms may be modified and fused to whole-body voxel models using the software presented in this work; user considerations for the open-source software and resultant phantoms are discussed. Furthermore, results indicate simulating breast models as predominantly fatty tissue can considerably underestimate the potential for tissue heating in women with substantial fibroglandular tissue.

Dataset Information

Toward 7T breast MRI clinical study: safety assessment using simulation of heterogeneous breast models in RF exposure.

Publications

Toward 7T breast MRI clinical study: safety assessment using simulation of heterogeneous breast models in RF exposure.

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