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Path integration maintains spatial periodicity of grid cell firing in a 1D circular track.

ABSTRACT: Entorhinal grid cells are thought to provide a 2D spatial metric of the environment. In this study we demonstrate that in a familiar 1D circular track (i.e., a continuous space) grid cells display a novel 1D equidistant firing pattern based on integrated distance rather than travelled distance or time. In addition, field spacing is increased compared to a 2D open field, probably due to a reduced access to the visual cue in the track. This metrical modification is accompanied by a change in LFP theta oscillations, but no change in intrinsic grid cell rhythmicity, or firing activity of entorhinal speed and head-direction cells. These results suggest that in a 1D circular space grid cell spatial selectivity is shaped by path integration processes, while grid scale relies on external information.

SUBMITTER: Jacob PY

PROVIDER: S-EPMC6381105 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Path integration maintains spatial periodicity of grid cell firing in a 1D circular track.

Jacob Pierre-Yves PY Capitano Fabrizio F Poucet Bruno B Save Etienne E Sargolini Francesca F

Nature communications 20190219 1

Entorhinal grid cells are thought to provide a 2D spatial metric of the environment. In this study we demonstrate that in a familiar 1D circular track (i.e., a continuous space) grid cells display a novel 1D equidistant firing pattern based on integrated distance rather than travelled distance or time. In addition, field spacing is increased compared to a 2D open field, probably due to a reduced access to the visual cue in the track. This metrical modification is accompanied by a change in LFP t ...[more]

PMID: 30783085

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