Ontology highlight
ABSTRACT:
SUBMITTER: Langford-Smith AWW
PROVIDER: S-EPMC6381138 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Langford-Smith Alexander W W AWW Hasan Ahmad A Weston Ria R Edwards Nicola N Jones Alan M AM Boulton Andrew J M AJM Bowling Frank L FL Rashid S Tawqeer ST Wilkinson Fiona L FL Alexander M Yvonne MY
Scientific reports 20190219 1
Endothelial colony forming progenitor cell (ECFC) function is compromised in diabetes, leading to poor vascular endothelial repair, which contributes to impaired diabetic foot ulcer healing. We have generated novel glycomimetic drugs with protective effects against endothelial dysfunction. We investigated the effect of glycomimetic C3 on the functional capacity of diabetic ECFCs. ECFCs were isolated from healthy controls and patients with diabetes with neuroischaemic (NI) or neuropathic (NP) foo ...[more]