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Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics.


ABSTRACT: Endothelial colony forming progenitor cell (ECFC) function is compromised in diabetes, leading to poor vascular endothelial repair, which contributes to impaired diabetic foot ulcer healing. We have generated novel glycomimetic drugs with protective effects against endothelial dysfunction. We investigated the effect of glycomimetic C3 on the functional capacity of diabetic ECFCs. ECFCs were isolated from healthy controls and patients with diabetes with neuroischaemic (NI) or neuropathic (NP) foot ulcers. Functionally, diabetic ECFCs demonstrated delayed colony formation (p?

SUBMITTER: Langford-Smith AWW 

PROVIDER: S-EPMC6381138 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics.

Langford-Smith Alexander W W AWW   Hasan Ahmad A   Weston Ria R   Edwards Nicola N   Jones Alan M AM   Boulton Andrew J M AJM   Bowling Frank L FL   Rashid S Tawqeer ST   Wilkinson Fiona L FL   Alexander M Yvonne MY  

Scientific reports 20190219 1


Endothelial colony forming progenitor cell (ECFC) function is compromised in diabetes, leading to poor vascular endothelial repair, which contributes to impaired diabetic foot ulcer healing. We have generated novel glycomimetic drugs with protective effects against endothelial dysfunction. We investigated the effect of glycomimetic C3 on the functional capacity of diabetic ECFCs. ECFCs were isolated from healthy controls and patients with diabetes with neuroischaemic (NI) or neuropathic (NP) foo  ...[more]

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