Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura S
PROVIDER: S-EPMC6381146 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nakamura Shuhei S Oba Masaki M Suzuki Mari M Takahashi Atsushi A Yamamuro Tadashi T Fujiwara Mari M Ikenaka Kensuke K Minami Satoshi S Tabata Namine N Yamamoto Kenichi K Kubo Sayaka S Tokumura Ayaka A Akamatsu Kanako K Miyazaki Yumi Y Kawabata Tsuyoshi T Hamasaki Maho M Fukui Koji K Sango Kazunori K Watanabe Yoshihisa Y Takabatake Yoshitsugu Y Kitajima Tomoya S TS Okada Yukinori Y Mochizuki Hideki H Isaka Yoshitaka Y Antebi Adam A Yoshimori Tamotsu T
Nature communications 20190219 1
Autophagy, an evolutionarily conserved cytoplasmic degradation system, has been implicated as a convergent mechanism in various longevity pathways. Autophagic activity decreases with age in several organisms, but the underlying mechanism is unclear. Here, we show that the expression of Rubicon, a negative regulator of autophagy, increases in aged worm, fly and mouse tissues at transcript and/or protein levels, suggesting that an age-dependent increase in Rubicon impairs autophagy over time, and ...[more]