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Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.

ABSTRACT: Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0.92-0.96; p < 0.001; n = 106 early-stage validation cohort, accuracy, 81%; AUC, 0.89; 95% CI, 0.83-0.95; p < 0.001), independent of age of the individuals, smoking habits, whole-blood storage time, and various inflammatory conditions. PSO enabled selection of gene panels to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.

SUBMITTER: Best MG 

PROVIDER: S-EPMC6381325 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.

Best Myron G MG   Sol Nik N   In 't Veld Sjors G J G SGJG   Vancura Adrienne A   Muller Mirte M   Niemeijer Anna-Larissa N AN   Fejes Aniko V AV   Tjon Kon Fat Lee-Ann LA   Huis In 't Veld Anna E AE   Leurs Cyra C   Le Large Tessa Y TY   Meijer Laura L LL   Kooi Irsan E IE   Rustenburg François F   Schellen Pepijn P   Verschueren Heleen H   Post Edward E   Wedekind Laurine E LE   Bracht Jillian J   Esenkbrink Michelle M   Wils Leon L   Favaro Francesca F   Schoonhoven Jilian D JD   Tannous Jihane J   Meijers-Heijboer Hanne H   Kazemier Geert G   Giovannetti Elisa E   Reijneveld Jaap C JC   Idema Sander S   Killestein Joep J   Heger Michal M   de Jager Saskia C SC   Urbanus Rolf T RT   Hoefer Imo E IE   Pasterkamp Gerard G   Mannhalter Christine C   Gomez-Arroyo Jose J   Bogaard Harm-Jan HJ   Noske David P DP   Vandertop W Peter WP   van den Broek Daan D   Ylstra Bauke B   Nilsson R Jonas A RJA   Wesseling Pieter P   Karachaliou Niki N   Rosell Rafael R   Lee-Lewandrowski Elizabeth E   Lewandrowski Kent B KB   Tannous Bakhos A BA   de Langen Adrianus J AJ   Smit Egbert F EF   van den Heuvel Michel M MM   Wurdinger Thomas T  

Cancer cell 20170801 2

Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.9  ...[more]

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