Ontology highlight
ABSTRACT:
SUBMITTER: Pan X
PROVIDER: S-EPMC6381606 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cell reports 20190201 8
The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear. Microtubule-associated protein MAP7 (ensconsin in Drosophila) is an essential kinesin-1 cofactor and promotes kinesin-1 recruitment to microtubules. Here, we found that MAP7 family member MAP7D2 concentrates at the proximal axon, where it overlaps with the axon initial segm ...[more]