Ontology highlight
ABSTRACT:
SUBMITTER: Picariello T
PROVIDER: S-EPMC6382014 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Picariello Tyler T Brown Jason M JM Hou Yuqing Y Swank Gregory G Cochran Deborah A DA King Oliver D OD Lechtreck Karl K Pazour Gregory J GJ Witman George B GB
Journal of cell science 20190211 3
Intraflagellar transport (IFT), which is essential for the formation and function of cilia in most organisms, is the trafficking of IFT trains (i.e. assemblies of IFT particles) that carry cargo within the cilium. Defects in IFT cause several human diseases. IFT trains contain the complexes IFT-A and IFT-B. To dissect the functions of these complexes, we studied a <i>Chlamydomonas</i> mutant that is null for the IFT-A protein IFT140. The mutation had no effect on IFT-B but destabilized IFT-A, pr ...[more]