Ontology highlight
ABSTRACT:
SUBMITTER: McPherson RL
PROVIDER: S-EPMC6382470 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
McPherson Robert Lyle RL Ong Shao-En SE Leung Anthony K L AKL
Methods in molecular biology (Clifton, N.J.) 20180101
ADP-ribosylation is a posttranslational modification that involves the conjugation of monomers and polymers of the small molecule ADP-ribose onto amino acid side chains. A family of ADP-ribosyltransferases catalyzes the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD<sup>+</sup>) onto a variety of amino acid side chains including aspartate, glutamate, lysine, arginine, cysteine, and serine. The monomeric form of the modification mono(ADP-ribosyl)ation (MARylation) is ...[more]