Ontology highlight
ABSTRACT:
SUBMITTER: Faisal M
PROVIDER: S-EPMC6382710 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Faisal Muhammad M Stark Helge H Büsche Guntram G Schlue Jerome J Teiken Kristin K Kreipe Hans H HH Lehmann Ulrich U Bartels Stephan S
Cancer medicine 20190111 2
Atypical chronic myeloid leukemia (aCML) and chronic myelomonocytic leukemia (CMML) represent two histologically and clinically overlapping myelodysplastic/myeloproliferative neoplasms. Also the mutational landscapes of both entities show congruencies. We analyzed and compared an aCML cohort (n = 26) and a CMML cohort (n = 59) by next-generation sequencing of 25 genes and by an nCounter approach for differential expression in 107 genes. Significant differences were found with regard to the mutat ...[more]