Mutational signatures and the genomic landscape of betel quid chewing-associated tongue carcinoma.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC6382727 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Mutational signatures and the genomic landscape of betel quid chewing-associated tongue carcinoma.
Zhang Weilong W Wang Mu M Wu Qifeng Q Zhu Qing Q Jiao Yuchen Y Zhu Yiming Y Yang Beibei B Ni Song S Yu Jianjun J Sun Hong H Zeng Yi-Xin YX
Cancer medicine 20190122 2
Our study presents the genetic landscape betel quid chewing-associated tongue carcinomas (BQ-TCs). We compared the genetic landscape and mutational signatures of 15 BQ-TCs, five nonbetel quid chewing-associated tongue carcinomas (nBQ-TCs), and 82 tongue carcinomas in general population from the TCGA (TCGA-TCs) project. The highlights of this research mainly include: (a) The genetic landscape of BQ-TC was characterized with frequent mutations in RASA1 gene and in CpG islands throughout the genome ...[more]
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2019-07-01 | GSE101761 | GEO
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