Ontology highlight
ABSTRACT:
SUBMITTER: Merceron C
PROVIDER: S-EPMC6382776 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Merceron Christophe C Ranganathan Kavitha K Wang Elizabeth E Tata Zachary Z Makkapati Shreya S Khan Mohd Parvez MP Mangiavini Laura L Yao Angela Qing AQ Castellini Laura L Levi Benjamin B Giaccia Amato J AJ Schipani Ernestina E
Bone research 20190221
Osteoblasts, which are the bone-forming cells, operate in a hypoxic environment. The transcription factors hypoxia-inducible factor-1α (HIF1) and HIF2 are key mediators of the cellular response to hypoxia. Both are expressed in osteoblasts. HIF1 is known to be a positive regulator of bone formation. Conversely, the role of HIF2 in the control osteoblast biology is still poorly understood. In this study, we used mouse genetics to demonstrate that HIF2 is an inhibitor of osteoblastogenesis and bon ...[more]