Ontology highlight
ABSTRACT:
SUBMITTER: Muraoka N
PROVIDER: S-EPMC6382796 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Muraoka Naoto N Nara Kaori K Tamura Fumiya F Kojima Hidenori H Yamakawa Hiroyuki H Sadahiro Taketaro T Miyamoto Kazutaka K Isomi Mari M Haginiwa Sho S Tani Hidenori H Kurotsu Shota S Osakabe Rina R Torii Satoru S Shimizu Shigeomi S Okano Hideyuki H Sugimoto Yukihiko Y Fukuda Keiichi K Ieda Masaki M
Nature communications 20190220 1
Direct cardiac reprogramming from fibroblasts can be a promising approach for disease modeling, drug screening, and cardiac regeneration in pediatric and adult patients. However, postnatal and adult fibroblasts are less efficient for reprogramming compared with embryonic fibroblasts, and barriers to cardiac reprogramming associated with aging remain undetermined. In this study, we screened 8400 chemical compounds and found that diclofenac sodium (diclofenac), a non-steroidal anti-inflammatory dr ...[more]