Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC6382836 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Wang Baocai B Kaufmann Benedikt B Engleitner Thomas T Lu Miao M Mogler Carolin C Olsavszky Victor V Öllinger Rupert R Zhong Suyang S Geraud Cyrill C Cheng Zhangjun Z Rad Roland R RR Schmid Roland M RM Friess Helmut H Hüser Norbert N Hartmann Daniel D von Figura Guido G
Scientific reports 20190220 1
Brahma-related gene 1 (Brg1), a catalytic subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, is known to be involved in proliferative cell processes. Liver regeneration is initiated spontaneously after injury and leads to a strong proliferative response. In this study, a hepatocyte-specific Brg1 gene knockout mouse model was used to analyse the role of Brg1 in liver regeneration by performing a 70% partial hepatectomy (PH). After PH, Brg1 was significantly upregulated in wildtype m ...[more]