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Helicobacter pylori eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study.


ABSTRACT:

Objective

To compare Helicobacter pylori (H. pylori) eradication rate of type 2 diabetic patients with non-diabetic subjects.

Methods

In this multicenter prospective observational study, H. pylori-infected subjects were enrolled from three university-affiliated hospitals. Eradication regimen was triple therapy with standard dose of proton pump inhibitors (b.i.d), amoxicillin (1.0 g b.i.d), and clarithromycin (500 mg b.i.d) for 7 days. Urea breath test was performed 4 weeks after treatment. Various clinical and laboratory data were collected for identification of factors associated with successful eradication.

Results

Totally, 144 subjects were enrolled and 119 (85 non-diabetic and 34 diabetic patients) were finally analyzed. Eradication rate was 75.6% and there was no difference between diabetic patients and non-diabetic subjects (73.5% vs 76.5%, p value: 0.814). Adverse drug reactions were reported in 44.5% of patients. In multivariate analysis for predicting H. pylori eradication in diabetic patients, HbA1c (⩾7.5%) was a significant factor affecting eradication rate (adjusted odds ratio: 0.100, 95% confidence interval: 0.011-0.909, p value: 0.041).

Conclusion

Diabetes itself is not a major factor affecting H. pylori eradication. However, poor glucose control may harmfully affect H. pylori eradication.

SUBMITTER: Nam SJ 

PROVIDER: S-EPMC6383094 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

<i>Helicobacter pylori</i> eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study.

Nam Seung-Joo SJ   Park Sung Chul SC   Lee Sang Hoon SH   Choi Dong Wook DW   Lee Sung Joon SJ   Bang Chang Seok CS   Baik Gwang Ho GH   Park Jong Kyu JK  

SAGE open medicine 20190219


<h4>Objective</h4>To compare <i>Helicobacter pylori</i> (<i>H. pylori</i>) eradication rate of type 2 diabetic patients with non-diabetic subjects.<h4>Methods</h4>In this multicenter prospective observational study, <i>H. pylori</i>-infected subjects were enrolled from three university-affiliated hospitals. Eradication regimen was triple therapy with standard dose of proton pump inhibitors (b.i.d), amoxicillin (1.0 g b.i.d), and clarithromycin (500 mg b.i.d) for 7 days. Urea breath test was perf  ...[more]

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