Ontology highlight
ABSTRACT:
SUBMITTER: Hassett KJ
PROVIDER: S-EPMC6383180 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Hassett Kimberly J KJ Benenato Kerry E KE Jacquinet Eric E Lee Aisha A Woods Angela A Yuzhakov Olga O Himansu Sunny S Deterling Jessica J Geilich Benjamin M BM Ketova Tatiana T Mihai Cosmin C Lynn Andy A McFadyen Iain I Moore Melissa J MJ Senn Joseph J JJ Stanton Matthew G MG Almarsson Örn Ö Ciaramella Giuseppe G Brito Luis A LA
Molecular therapy. Nucleic acids 20190207
mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to fully realizing the potential of mRNA vaccines. Pre-clinical and clinical studies have demonstrated that mRNA delivered intramuscularly (IM) with first-generation lipid nanoparticles (LNPs) generates robust immune responses. Despite progress made over the past several years, there remains signifi ...[more]