Dataset Information

Glial activation and inflammation along the Alzheimer's disease continuum.

ABSTRACT:

Background

Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid (CSF) neuronal and glia markers along the AD continuum, to reveal putative protective or harmful stage-dependent patterns of activation.

Methods

We included healthy controls (n?=?36) and A?-positive (A?+) cases (as defined by pathological CSF amyloid beta 1-42 (A?42)) with either subjective cognitive decline (SCD, n?=?19), mild cognitive impairment (MCI, n?=?39), or AD dementia (n?=?27). The following CSF markers were measured: a microglial activation marker-soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a marker of microglial inflammatory reaction-monocyte chemoattractant protein-1 (MCP-1), two astroglial activation markers-chitinase-3-like protein 1 (YKL-40) and clusterin, a neuron-microglia communication marker-fractalkine, and the CSF AD biomarkers (A?42, phosphorylated tau (P-tau), total tau (T-tau)). Using ANOVA with planned comparisons, or Kruskal-Wallis tests with Dunn's pairwise comparisons, CSF levels were compared between clinical groups and between stages of biomarker severity using CSF biomarkers for classification based on amyloid pathology (A), tau pathology (T), and neurodegeneration (N) giving rise to the A/T/N score.

Results

Compared to healthy controls, sTREM2 was increased in SCD (p?DiscussionMicroglial activation as indicated by increased sTREM2 is present already at the preclinical SCD stage; increased MCP-1 and astroglial activation markers (YKL-40 and clusterin) were noted only at the MCI and AD dementia stages, respectively, and in A?+ cases (A+) with pathological T-tau (N+). Possible different effects of early and later glial activation need to be explored.

SUBMITTER: Nordengen K

PROVIDER: S-EPMC6383268 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Publications

Glial activation and inflammation along the Alzheimer's disease continuum.

Nordengen Kaja K Kirsebom Bjørn-Eivind BE Henjum Kristi K Selnes Per P Gísladóttir Berglind B Wettergreen Marianne M Torsetnes Silje Bøen SB Grøntvedt Gøril Rolfseng GR Waterloo Knut K KK Aarsland Dag D Nilsson Lars N G LNG Fladby Tormod T

Journal of neuroinflammation 20190221 1

<h4>Background</h4>Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid (CSF) neuronal and glia markers along the AD continuum, to reveal putative protective or harmful stage-dependent patterns of activation.<h4>Methods</h4>We included healthy controls (n = 36) and Aβ-positive (Aβ+) cases (as defined by pathological CSF amyloid beta 1-42 (Aβ42)) with either subjective cognitive decline (SCD, n = ...[more]

PMID: 30791945

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Dataset Information

Glial activation and inflammation along the Alzheimer's disease continuum.

Background

Methods

Results

Publications

Glial activation and inflammation along the Alzheimer's disease continuum.

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