Ontology highlight
ABSTRACT:
SUBMITTER: Weltrowska G
PROVIDER: S-EPMC6383560 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Weltrowska Grazyna G Nguyen Thi M-D TM Chung Nga N NN Wilkes Brian C BC Schiller Peter W PW
Peptide science (Hoboken, N.J.) 20180525 1
Head-to-tail cyclized analogues of the μ opioid receptor (MOR) agonist tetrapeptides DALDA (H-Tyr-D-Arg-Phe-Lys-NH<sub>2</sub> and [Dmt<sup>1</sup>]DALDA (H-Dmt-D-Arg-Phe-Lys-NH<sub>2</sub>; Dmt = 2',6'-dimethyltyrosine) and their enantiomers (mirror-image isomers) were synthesized and pharmacologically characterized in vitro. Three pairs of enantiomeric cyclic peptides with both mirror-image isomers having equipotent MOR binding affinities but different binding affinities at the δ and κ opioid ...[more]