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Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.


ABSTRACT: BACKGROUND:Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this. OBJECTIVE:To explore the in vivo relationships between MRS and PET [11C]PBR28 in MS over a range of brain inflammatory burden. METHODS:A total of 23 patients were studied. TSPO PET imaging with [11C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability was assessed by Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC). RESULTS:[11C]PBR28 uptake and [ myo-inositol] were not associated. When the whole cohort was stratified by higher [11C]PBR28 inflammatory burden, [ myo-inositol] was positively correlated to [11C]PBR28 uptake (Spearman's ??=?0.685, p?=?0.014). Moderate correlations were found between [11C]PBR28 uptake and both MRS creatine normalised N-acetyl aspartate (NAA) concentration and grey matter volume. MSFC was correlated with grey matter volume (??=?0.535, p?=?0.009). There were no associations between other imaging or clinical measures. CONCLUSION:MRS [ myo-inositol] and PET [11C]PBR28 measure independent inflammatory processes which may be more commonly found together with more severe inflammatory disease. Microglial activation measured by [11C]PBR28 uptake was associated with loss of neuronal integrity and grey matter atrophy.

SUBMITTER: Datta G 

PROVIDER: S-EPMC6383749 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.

Datta Gourab G   Violante Ines R IR   Scott Gregory G   Zimmerman Karl K   Santos-Ribeiro Andre A   Rabiner Eugenii A EA   Gunn Roger N RN   Malik Omar O   Ciccarelli Olga O   Nicholas Richard R   Matthews Paul M PM  

Multiple sclerosis (Houndmills, Basingstoke, England) 20161207 11


<h4>Background</h4>Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this.<h4>Objective</h4>To explore the in vivo relationships between MRS and PET [<sup>11</sup>C]PBR28 in MS over a range of brain inflammatory burden.<h4>Methods</h4>A total of 23 patients were studied. TSPO PET  ...[more]

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