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Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water.

ABSTRACT: A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.

SUBMITTER: Long Y

PROVIDER: S-EPMC6384643 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water.

Long Yang Y Pan Lei L Zhou Xiangge X

Molecules (Basel, Switzerland) 20190201 3

A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process. ...[more]

PMID: 30717184

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