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Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids.

ABSTRACT: A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.

SUBMITTER: Zhang W

PROVIDER: S-EPMC6385076 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids.

Zhang Wuyuan W Ma Ming M Huijbers Mieke M E MME Filonenko Georgy A GA Pidko Evgeny A EA van Schie Morten M de Boer Sabrina S Burek Bastien O BO Bloh Jonathan Z JZ van Berkel Willem J H WJH Smith Wilson A WA Hollmann Frank F

Journal of the American Chemical Society 20190206 7

A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. The ...[more]

PMID: 30673222

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