New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment.

ABSTRACT:

Background

Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients that carry alterations in homologous DNA repair genes, letting to envisage susceptibility to the Poly (adenosine diphosphate [ADP]) ribose polymerase (PARP) inhibitors.

Main body

PARP inhibition, by amplifying the DNA damage, augments the mutational burden and promotes the immune priming of the tumor by increasing the neoantigen exposure and determining upregulation of programmed death ligand 1 (PD-L1) expression. Thus, the combination of PARP-inhibition and the PD/PD-L1 targeting may represent a compelling strategy to treat bladder cancer and has been intro

SUBMITTER: Criscuolo D 

PROVIDER: S-EPMC6385418 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature