Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis.

ABSTRACT:

Background

Asthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of studies have identified the association between a disintegrin and metalloprotease 33 (ADAM33) polymorphisms and asthma risk, however, the results still remain inconclusive. The objective of the present study was to identify the effect of ADAM33 variants in asthma susceptibility.

Methods

Eligible case-control studies published between January 2000 and June 2018 was searched and retrieved from online electronic databases. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the effect.

Results

A total of 63 case-control stud

SUBMITTER: Li HF 

PROVIDER: S-EPMC6385425 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature