Ontology highlight
ABSTRACT:
SUBMITTER: Park YH
PROVIDER: S-EPMC6385489 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Park Yong H YH Snook Joshua D JD Ostrin Edwin J EJ Kim Sangbae S Chen Rui R Frankfort Benjamin J BJ
Scientific reports 20190222 1
Elevated intraocular pressure (IOP) is the major risk factor for glaucoma, a sight threatening disease of retinal ganglion cells (RGCs) and their axons. Despite the central importance of IOP, details of the impact of IOP elevation on RGC gene expression remain elusive. We developed a 4-step immunopanning protocol to extract adult mouse RGCs with high fidelity and used it to isolate RGCs from wild type mice exposed to 2 weeks of IOP elevation generated by the microbead model. IOP was elevated to ...[more]