Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration.

ABSTRACT:

Objectives

A correlation exists between breast cancer and thyroid disorders, which are common in elderly women. Thyroid hormones are degraded into trace amines, which can bind to the G-protein-coupled receptor trace amine-associated receptor 1 (TAAR1) and thereby activate it. The transformation of thyroid hormones into trace amines is carried out by the ornithine decarboxylase. Previously, we showed that TAAR1 overexpression (IRS ≥6) was associated with a significantly longer OS in primary breast cancer patients during a long-term follow-up of up to 14 years. Aim of the present study was to analyze the regulation of TAAR1 in breast cancer cell lines and the influence of triiodothyronine (T₃), thyronamines, and tetraiodothyroacetic acid (Tetrac) on the expression of TAAR1

SUBMITTER: Tremmel E 

PROVIDER: S-EPMC6385785 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature