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Development of novel biocompatible thermosensitive anti-adhesive agents using human-derived acellular dermal matrix.


ABSTRACT: Postoperative adhesion is a natural phenomenon that occurs in damaged tissue cells. Several anti-adhesion agents are currently used, but there is no leading-edge product with excellent adhesion-preventive effects. The purpose of this study was to develop ideal anti-adhesive agents using human-derived acellular dermal matrix (ADM). We developed 5 new biocompatible thermosensitive anti-adhesion barriers (AABs) using micronized human-derived ADM, hyaluronic acid, and temperature-sensitive and biocompatible synthesized polymers. The biocompatibility, anti-adhesion effect, and biodegradability of these AABs were compared with those of commercial thermosensitive anti-adhesion agents. No cytotoxic effects were observed in vitro and in vivo. Animal testing of adhesion resistance confirmed that the adhesion area, strength, and grade of AAB03 were statistically superior to those of the control group. Factors related to adhesion formation, such as lymphocytes, macrophages, microvessels, and collagen fiber density, were observed using specific staining methods; the results confirmed that AAB03 group exhibited significantly lower macrophage counts, microvessel density, and collagen fiber density than the control groups. Furthermore, AAB03 was completely absorbed by 6 weeks. Thus, AAB03 has the potential to be used as a high-performance anti-adhesion agent.

SUBMITTER: Jeong JJ 

PROVIDER: S-EPMC6386309 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Development of novel biocompatible thermosensitive anti-adhesive agents using human-derived acellular dermal matrix.

Jeong Jong Ju JJ   Lee Dong Won DW   Song Seung Yong SY   Park Yerin Y   Kim Ji Hee JH   Kim Jang Il JI   Kim Hyung Goo HG   Nam Ki Taek KT   Lee Won Jai WJ   Nam Kee-Hyun KH   Lee Ju Hee JH  

PloS one 20190222 2


Postoperative adhesion is a natural phenomenon that occurs in damaged tissue cells. Several anti-adhesion agents are currently used, but there is no leading-edge product with excellent adhesion-preventive effects. The purpose of this study was to develop ideal anti-adhesive agents using human-derived acellular dermal matrix (ADM). We developed 5 new biocompatible thermosensitive anti-adhesion barriers (AABs) using micronized human-derived ADM, hyaluronic acid, and temperature-sensitive and bioco  ...[more]

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