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Correlation Structure in Micro-ECoG Recordings is Described by Spatially Coherent Components.

ABSTRACT: Electrocorticography (ECoG) is becoming more prevalent due to improvements in fabrication and recording technology as well as its ease of implantation compared to intracortical electrophysiology, larger cortical coverage, and potential advantages for use in long term chronic implantation. Given the flexibility in the design of ECoG grids, which is only increasing, it remains an open question what geometry of the electrodes is optimal for an application. Conductive polymer, PEDOT:PSS, coated microelectrodes have an advantage that they can be made very small without losing low impedance. This makes them suitable for evaluating the required granularity of ECoG recording in humans and experimental animals. We used two-dimensional (2D) micro-ECoG grids to record intra-operatively in humans and during acute implantations in mouse with separation distance between neighboring electrodes (i.e., pitch) of 0.4 mm and 0.2/0.25 mm respectively. To assess the spatial properties of the signals, we used the average correlation between electrodes as a function of the pitch. In agreement with prior studies, we find a strong frequency dependence in the spatial scale of correlation. By applying independent component analysis (ICA), we find that the spatial pattern of correlation is largely due to contributions from multiple spatially extended, time-locked sources present at any given time. Our analysis indicates the presence of spatially structured activity down to the sub-millimeter spatial scale in ECoG despite the effects of volume conduction, justifying the use of dense micro-ECoG grids.

SUBMITTER: Rogers N

PROVIDER: S-EPMC6386410 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Correlation Structure in Micro-ECoG Recordings is Described by Spatially Coherent Components.

Rogers Nicholas N Hermiz John J Ganji Mehran M Kaestner Erik E Kılıç Kıvılcım K Hossain Lorraine L Thunemann Martin M Cleary Daniel R DR Carter Bob S BS Barba David D Devor Anna A Halgren Eric E Dayeh Shadi A SA Gilja Vikash V

PLoS computational biology 20190211 2

Electrocorticography (ECoG) is becoming more prevalent due to improvements in fabrication and recording technology as well as its ease of implantation compared to intracortical electrophysiology, larger cortical coverage, and potential advantages for use in long term chronic implantation. Given the flexibility in the design of ECoG grids, which is only increasing, it remains an open question what geometry of the electrodes is optimal for an application. Conductive polymer, PEDOT:PSS, coated micr ...[more]

PMID: 30742605

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Project description:Micro-electrocorticography (?ECoG) offers a minimally invasive neural interface with high spatial resolution over large areas of cortex. However, electrode arrays with many contacts that are individually wired to external recording systems are cumbersome and make recordings in freely behaving rodents challenging. We report a novel high-density 60-electrode system for ?ECoG recording in freely moving rats.Multiplexed headstages overcome the problem of wiring complexity by combining signals from many electrodes to a smaller number of connections. We have developed a low-cost, multiplexed recording system with 60 contacts at 406 ?m spacing. We characterized the quality of the electrode signals using multiple metrics that tracked spatial variation, evoked-response detectability, and decoding value. Performance of the system was validated both in anesthetized animals and freely moving awake animals.We recorded ?ECoG signals over the primary auditory cortex, measuring responses to acoustic stimuli across all channels. Single-trial responses had high signal-to-noise ratios (SNR) (up to 25 dB under anesthesia), and were used to rapidly measure network topography within ?10 s by constructing all single-channel receptive fields in parallel. We characterized evoked potential amplitudes and spatial correlations across the array in the anesthetized and awake animals. Recording quality in awake animals was stable for at least 30 days. Finally, we used these responses to accurately decode auditory stimuli on single trials.This study introduces (1) a ?ECoG recording system based on practical hardware design and (2) a rigorous analytical method for characterizing the signal characteristics of ?ECoG electrode arrays. This methodology can be applied to evaluate the fidelity and lifetime of any ?ECoG electrode array. Our ?ECoG-based recording system is accessible and will be useful for studies of perception and decision-making in rodents, particularly over the entire time course of behavioral training and learning.

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Correlation Structure in Micro-ECoG Recordings is Described by Spatially Coherent Components.

Publications

Correlation Structure in Micro-ECoG Recordings is Described by Spatially Coherent Components.

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