A Hepatocyte-Mimicking Antidote for Alcohol Intoxication.
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ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC6386471 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
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A Hepatocyte-Mimicking Antidote for Alcohol Intoxication.
Xu Duo D Han Hui H He Yuxin Y Lee Harrison H Wu Di D Liu Fang F Liu Xiangsheng X Liu Yang Y Lu Yunfeng Y Ji Cheng C
Advanced materials (Deerfield Beach, Fla.) 20180411 22
Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. Upon alcohol consumption, alcohol is sequentially oxidized to acetaldehyde and acetate by the endogenous alcohol dehydrogenase and aldehyde dehydrogenase, respectively. Inspired by the metabolism of alcohol, a hepatocyte-mimicking antidote for alcohol intoxication through the codelivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde ...[more]
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