Ontology highlight
ABSTRACT:
SUBMITTER: Hartley-Tassell LE
PROVIDER: S-EPMC6386544 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Hartley-Tassell Lauren E LE Awad Milena M MM Seib Kate L KL Scarselli Maria M Savino Silvana S Tiralongo Joe J Lyras Dena D Day Christopher J CJ Jennings Michael P MP
Infection and immunity 20190221 3
<i>Clostridium difficile</i> is a major cause of hospital-acquired antibiotic-associated diarrhea. <i>C. difficile</i> produces two cytotoxins, TcdA and TcdB; both toxins are multidomain proteins that lead to cytotoxicity through the modification and inactivation of small GTPases of the Rho/Rac family. Previous studies have indicated that host glycans are targets for TcdA and TcdB, with interactions thought to be with both α- and β-linked galactose. In the current study, screening of glycan arra ...[more]