Persistent metabolic youth in the aging female brain.
Ontology highlight
ABSTRACT:
SUBMITTER: Goyal MS
PROVIDER: S-EPMC6386682 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Persistent metabolic youth in the aging female brain.
Goyal Manu S MS Blazey Tyler M TM Su Yi Y Couture Lars E LE Durbin Tony J TJ Bateman Randall J RJ Benzinger Tammie L-S TL Morris John C JC Raichle Marcus E ME Vlassenko Andrei G AG
Proceedings of the National Academy of Sciences of the United States of America 20190204 8
Sex differences influence brain morphology and physiology during both development and aging. Here we apply a machine learning algorithm to a multiparametric brain PET imaging dataset acquired in a cohort of 20- to 82-year-old, cognitively normal adults (<i>n</i> = 205) to define their metabolic brain age. We find that throughout the adult life span the female brain has a persistently lower metabolic brain age-relative to their chronological age-compared with the male brain. The persistence of re ...[more]
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