Ontology highlight
ABSTRACT:
SUBMITTER: Sakuragi T
PROVIDER: S-EPMC6386700 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Sakuragi Takaharu T Kosako Hidetaka H Nagata Shigekazu S
Proceedings of the National Academy of Sciences of the United States of America 20190204 8
The exposure of phosphatidylserine (PtdSer) to the cell surface is regulated by the down-regulation of flippases and the activation of scramblases. Xkr8 has been identified as a scramblase that is activated during apoptosis, but its exogenous expression in the mouse Ba/F3 pro B cell line induces constitutive PtdSer exposure. Here we found that this Xkr8-mediated PtdSer exposure occurred at 4 °C, but not at 20 °C, although its scramblase activity was observed at 20 °C. The Xkr8-mediated PtdSer ex ...[more]