Ontology highlight
ABSTRACT:
SUBMITTER: Ripin N
PROVIDER: S-EPMC6386705 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Ripin Nina N Boudet Julien J Duszczyk Malgorzata M MM Hinniger Alexandra A Faller Michael M Krepl Miroslav M Gadi Abhilash A Schneider Robert J RJ Šponer Jiří J Meisner-Kober Nicole C NC Allain Frédéric H-T FH
Proceedings of the National Academy of Sciences of the United States of America 20190204 8
Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate-rich elements (AU-rich elements; AREs). These are a major class of <i>cis</i> elements within 3' untranslated regions, targeting these mRNAs for rapid degradation. HuR contains three RNA recognition motifs (RRMs): a tandem RRM1 and 2, followed by a flexible linker and a C-terminal RRM3. While RRM1 and 2 are structurally characterized, little is known about RRM3. Here we present a 1.9-Å-resolution crystal st ...[more]