Ontology highlight
ABSTRACT:
SUBMITTER: Croft NP
PROVIDER: S-EPMC6386720 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Croft Nathan P NP Smith Stewart A SA Pickering Jana J Sidney John J Peters Bjoern B Faridi Pouya P Witney Matthew J MJ Sebastian Prince P Flesch Inge E A IEA Heading Sally L SL Sette Alessandro A La Gruta Nicole L NL Purcell Anthony W AW Tscharke David C DC
Proceedings of the National Academy of Sciences of the United States of America 20190204 8
CD8<sup>+</sup> T cells are essential effectors in antiviral immunity, recognizing short virus-derived peptides presented by MHC class I (pMHCI) on the surface of infected cells. However, the fraction of viral pMHCI on infected cells that are immunogenic has not been shown for any virus. To approach this fundamental question, we used peptide sequencing by high-resolution mass spectrometry to identify more than 170 vaccinia virus pMHCI presented on infected mouse cells. Next, we screened each pep ...[more]