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Differences in the genetic backgrounds of patients with alcoholic liver disease and non-alcoholic fatty liver disease.

ABSTRACT: Background and Aim:Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have common hepatic histological features, but few studies have compared the genomic backgrounds of these two diseases. Here, we compared the genetic differences between ALD and NAFLD. Methods:This study enrolled 318 Japanese patients with ALD (n?=?118; male, 86%; median age, 62?years; liver cirrhosis, 58%; hepatocellular carcinoma [HCC], 31%) and NAFLD (n?=?200; male, 55%; age, 61?years; cirrhosis, 19%; HCC, 12%). The genotype frequencies of 10 single nucleotide polymorphisms (SNPs) were analyzed. Results:The ADH1B genotype GG and ALDH2 genotype GG were observed more frequently, and the percentage of patients with the MTP genotype GG was lower in ALD compared with NAFLD patients (ADH1B, 16 vs 4%; ALDH2 84 vs 44%; MTP 62 vs 72%, respectively; all P?

SUBMITTER: Yamamoto K

PROVIDER: S-EPMC6386744 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Differences in the genetic backgrounds of patients with alcoholic liver disease and non-alcoholic fatty liver disease.

Yamamoto Kuniko K Kogiso Tomomi T Taniai Makiko M Hashimoto Etsuko E Tokushige Katsutoshi K

JGH open : an open access journal of gastroenterology and hepatology 20181017 1

<h4>Background and aim</h4>Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have common hepatic histological features, but few studies have compared the genomic backgrounds of these two diseases. Here, we compared the genetic differences between ALD and NAFLD.<h4>Methods</h4>This study enrolled 318 Japanese patients with ALD (<i>n</i> = 118; male, 86%; median age, 62 years; liver cirrhosis, 58%; hepatocellular carcinoma [HCC], 31%) and NAFLD (<i>n</i> = 200; male, 55%; ...[more]

PMID: 30834336

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