Drug Development for Alzheimer's Disease: Microglia Induced Neuroinflammation as a Target?
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ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC6386861 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Drug Development for Alzheimer's Disease: Microglia Induced Neuroinflammation as a Target?
Dong Yuan Y Li Xiaoheng X Cheng Jinbo J Hou Lin L
International journal of molecular sciences 20190128 3
Alzheimer's disease (AD) is one of the most common causes of dementia. Its pathogenesis is characterized by the aggregation of the amyloid-β (Aβ) protein in senile plaques and the hyperphosphorylated tau protein in neurofibrillary tangles in the brain. Current medications for AD can provide temporary help with the memory symptoms and other cognitive changes of patients, however, they are not able to stop or reverse the progression of AD. New medication discovery and the development of a cure for ...[more]
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