Ontology highlight
ABSTRACT:
SUBMITTER: Yasuda K
PROVIDER: S-EPMC6387150 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Yasuda Koubun K Nakanishi Kenji K Tsutsui Hiroko H
International journal of molecular sciences 20190202 3
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. Therefore, IL-12 is a commitment factor that induces the development of Th1 cells. In contrast, IL-18 is a proinflammatory cytokine that facilitates type 1 respon ...[more]