Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects.
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ABSTRACT:
SUBMITTER: Mohamad NA
PROVIDER: S-EPMC6387522 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects.
Mohamad Nur Afiqah NA Ramachandran Vasudevan V Mohd Isa Hazlita H Chan Yoke Mun YM Ngah Nor Fariza NF Ching Siew Mooi SM Hoo Fan Kee FK Wan Sulaiman Wan Aliaa WA Inche Mat Liyana Najwa LN Mohamed Mohd Hazmi MH
Human genomics 20190222 1
<h4>Background</h4>The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes.<h4>Results</h4>Both single nucleotide polymorphisms (SNPs) recorded a significant association between nAMD and controls with HTRA1 rs11200638 at P = 0.018 (OR = 1.52, 95% CI = 1.07-215) and ARMS2 rs10490924 at P < 0.001 (O ...[more]
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