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Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects.

ABSTRACT: BACKGROUND:The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes. RESULTS:Both single nucleotide polymorphisms (SNPs) recorded a significant association between nAMD and controls with HTRA1 rs11200638 at P?=?0.018 (OR?=?1.52, 95% CI?=?1.07-215) and ARMS2 rs10490924 at P?

SUBMITTER: Mohamad NA 

PROVIDER: S-EPMC6387522 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects.

Mohamad Nur Afiqah NA   Ramachandran Vasudevan V   Mohd Isa Hazlita H   Chan Yoke Mun YM   Ngah Nor Fariza NF   Ching Siew Mooi SM   Hoo Fan Kee FK   Wan Sulaiman Wan Aliaa WA   Inche Mat Liyana Najwa LN   Mohamed Mohd Hazmi MH  

Human genomics 20190222 1

<h4>Background</h4>The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes.<h4>Results</h4>Both single nucleotide polymorphisms (SNPs) recorded a significant association between nAMD and controls with HTRA1 rs11200638 at P = 0.018 (OR = 1.52, 95% CI = 1.07-215) and ARMS2 rs10490924 at P < 0.001 (O  ...[more]

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