Systematic discovery of antiphage defense systems in the microbial pangenome.
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ABSTRACT:
SUBMITTER: Doron S
PROVIDER: S-EPMC6387622 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Systematic discovery of antiphage defense systems in the microbial pangenome.
Doron Shany S Melamed Sarah S Ofir Gal G Leavitt Azita A Lopatina Anna A Keren Mai M Amitai Gil G Sorek Rotem R
Science (New York, N.Y.) 20180125 6379
The arms race between bacteria and phages led to the development of sophisticated antiphage defense systems, including CRISPR-Cas and restriction-modification systems. Evidence suggests that known and unknown defense systems are located in "defense islands" in microbial genomes. Here, we comprehensively characterized the bacterial defensive arsenal by examining gene families that are clustered next to known defense genes in prokaryotic genomes. Candidate defense systems were systematically engin ...[more]
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