Ontology highlight
ABSTRACT:
SUBMITTER: Wolfe MB
PROVIDER: S-EPMC6387853 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Wolfe Michael B MB Goldstrohm Aaron C AC Freddolino Peter L PL
Methods (San Diego, Calif.) 20181206
Many open questions in RNA biology relate to the kinetics of gene expression and the impact of RNA binding regulatory factors on processing or decay rates of particular transcripts. Steady state measurements of RNA abundance obtained from RNA-seq approaches are not able to separate the effects of transcription from those of RNA decay in the overall abundance of any given transcript, instead only giving information on the (presumed steady-state) abundances of transcripts. Through the combination ...[more]