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Diet-related inflammation and risk of prostate cancer in the California Men's Health Study.

ABSTRACT: PURPOSE:The purpose of the study was to examine the relationship between proinflammatory diet and prostate cancer risk. METHODS:Energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed among 40,161 participants in the California Men's Health Study. Over 9.7 ± 3.8 years of follow-up, 2707 incident prostate cancer cases were diagnosed and categorized as low-, intermediate-, or high-risk, based on disease grade and stage. Accelerated failure-time models assessed time to diagnosis of prostate cancer. Cox proportional hazard models estimated hazard ratios (HR) and 95% confidence intervals (95% CI). Nonlinear effects of E-DII were modeled as third-order polynomials. RESULTS:Time to prostate cancer diagnosis did not differ by E-DII quartile. The HR for high-risk prostate cancer increased in the third E-DII quartile (HRQ3 vs. Q1 = 1.36; 95% CI: 1.04-1.76), but not in the fourth (HRQ4 vs. Q1 = 0.99; 95% CI: 0.74-1.32, Ptrend = .74), suggesting a nonlinear dose-response. HR curves for prostate cancer increased exponentially above an E-DII threshold of ?+3.0. HR curves for high-risk prostate cancer had a much steeper incline above an E-DII threshold of ?+2.5. Curves were higher among Blacks and Whites relative to other races and among overweight or obese men. No relationship was observed between E-DII scores and intermediate- or low-risk disease. CONCLUSIONS:Relationships between proinflammatory diet and prostate cancer risk may be nonlinear, with an increased risk above an E-DII threshold of ?+2.5.

SUBMITTER: McMahon DM

PROVIDER: S-EPMC6388401 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Diet-related inflammation and risk of prostate cancer in the California Men's Health Study.

McMahon Daria M DM Burch James B JB Hébert James R JR Hardin James W JW Zhang Jiajia J Wirth Michael D MD Youngstedt Shawn D SD Shivappa Nitin N Jacobsen Steven J SJ Caan Bette B Van Den Eeden Stephen K SK

Annals of epidemiology 20181102

<h4>Purpose</h4>The purpose of the study was to examine the relationship between proinflammatory diet and prostate cancer risk.<h4>Methods</h4>Energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed among 40,161 participants in the California Men's Health Study. Over 9.7 ± 3.8 years of follow-up, 2707 incident prostate cancer cases were diagnosed and categorized as low-, intermediate-, or high-risk, based on disease grade and stage. Accelerated failure-time models assessed time t ...[more]

PMID: 30503073

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Project description:BackgroundThere are few prospective studies comparing race-specific associations between diet, nutrients, and health-related parameters, and prostate cancer risk.MethodsRace-specific prostate cancer risk associations were examined among men in the National Institutes of Health (NIH)-AARP Diet and Health Study. We identified 1417 cases among black men (209 advanced), and 28,845 among white men (3898 advanced). Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). We also evaluated the cumulative change in the HR for black race following adjustment for each factor.ResultsRace-specific prostate cancer associations were similar in black and white men across disease subtypes only for history of diabetes (overall : HR = 0.77, 95% CI: 0.65-0.90 and HR = 0.72, 95% CI: 0.69-0.76, respectively; Pinteraction = 0.66). By contrast, there was a positive risk association with height for white men and inverse for black men (Pinteraction: non-advanced = 0.01; advanced = 0.04). This difference remained among men with at least 2 years of follow-up for non-advanced (Pinteraction = 0.01), but not advanced disease (Pinteraction = 0.24); or after adjustment for prostate cancer screening (non-advanced Pinteraction = 0.53, advanced Pinteraction = 0.31). The only other evidence of interaction with race was observed for dietary vitamin D intake and non-advanced disease, but only after adjustment for screening (Pinteraction = 0.02). Cumulative adjustment for each factor increased the HR for black race by 32.9% for overall cancer and 12.4% for advanced disease.ConclusionsOur data suggest few of the dietary, nutrient, and health-related factors associated with prostate cancer risk in predominantly non-Hispanic white men were associated with risk in black men, and adjustment for these factors widen the black-white difference in risk. Larger studies of black men, particularly with prospective data, are needed to help identify risk factors relevant to this population.

Dataset Information

Diet-related inflammation and risk of prostate cancer in the California Men's Health Study.

Publications

Diet-related inflammation and risk of prostate cancer in the California Men's Health Study.

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