Ontology highlight
ABSTRACT:
SUBMITTER: Shirota H
PROVIDER: S-EPMC6388689 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Shirota Hidekazu H Klinman Dennis M DM
Cancer immunology, immunotherapy : CII 20110204 5
The primary goal of cancer immunotherapy is to elicit an immune response capable of eradicating established tumors and preventing tumor metastasis. One strategy to achieve this goal utilizes whole killed tumor cells as the primary immunogen. Killed tumor cells provide a comprehensive source of tumor-associated antigens (TAAs), thereby eliminating the need to identify individual antigens. Unfortunately, killed tumor cells tend to be poorly immunogenic. To overcome this limitation, we covalently c ...[more]