The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent.
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ABSTRACT: Impact statement
The main challenge in bone morphogenic protein 2 (BMP-2)-based application lies in finding strategies to prolong its biologic activity as it has a short biological half-life. The present study uses a phosphate-modified oligo[(polyethylene glycol) fumarate] hydrogel that can be tuned to achieve differential release profiles of biologically active BMP-2 release. We demonstrate that this platform outperforms Infuse®, currently used in the clinic and that the osteoinductive effect of BMP-2 is location dependent. Altogether, this study stresses the importance of evaluating efficacy of bone tissue engineering strategies at an orthotopic location rather than subcutaneously. Even more so, it emphasizes the role of biomaterials as a scaffold to achieve proper bone tissue engineering.
SUBMITTER: Olthof MGL
PROVIDER: S-EPMC6388716 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent.
Olthof Maurits G L MGL Lu Lichun L Tryfonidou Marianna A MA Loozen Loek D LD Pouran Behdad B Yaszemski Michael J MJ Meij Björn P BP Dhert Wouter J A WJA Alblas Jacqueline J Kempen Diederik H R DHR
Tissue engineering. Part A 20190130 3-4
<h4>Impact statement</h4>The main challenge in bone morphogenic protein 2 (BMP-2)-based application lies in finding strategies to prolong its biologic activity as it has a short biological half-life. The present study uses a phosphate-modified oligo[(polyethylene glycol) fumarate] hydrogel that can be tuned to achieve differential release profiles of biologically active BMP-2 release. We demonstrate that this platform outperforms Infuse<sup>®</sup>, currently used in the clinic and that the oste ...[more]
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