Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Rincon J
PROVIDER: S-EPMC6388933 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
González-Rincón Julia J Méndez Miriam M Gómez Sagrario S García Juan F JF Martín Paloma P Bellas Carmen C Pedrosa Lucía L Rodríguez-Pinilla Socorro M SM Camacho Francisca I FI Quero Cristina C Pérez-Callejo David D Rueda Antonio A Llanos Marta M Gómez-Codina José J Piris Miguel A MA Montes-Moreno Santiago S Bárcena Carmen C Rodríguez-Abreu Delvys D Menárguez Javier J de la Cruz-Merino Luis L Monsalvo Silvia S Parejo Consuelo C Royuela Ana A Kwee Ivo I Cascione Luciano L Arribas Alberto A Bertoni Francesco F Mollejo Manuela M Provencio Mariano M Sánchez-Beato Margarita M
PloS one 20190225 2
Follicular lymphoma (FL) is an indolent but largely incurable disease. Some patients suffer histological transformation to a more aggressive subtype with poorer prognosis. This study aimed to improve our understanding of the genetics underlying FL histological transformation, and to identify genetic drivers or promoters of the transformation by elucidating the differences between FL samples from patients who did and did not transform. We conducted targeted massive parallel sequencing of 22 pre-t ...[more]