Ontology highlight
ABSTRACT:
SUBMITTER: Johnson SC
PROVIDER: S-EPMC6389356 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Johnson Simon C SC Martinez Frank F Bitto Alessandro A Gonzalez Brenda B Tazaerslan Cagdas C Cohen Camille C Delaval Laure L Timsit José J Knebelmann Bertrand B Terzi Fabiola F Mahal Tarika T Zhu Yizhou Y Morgan Philip G PG Sedensky Margaret M MM Kaeberlein Matt M Legendre Christophe C Suh Yousin Y Canaud Guillaume G
Kidney international 20181122 2
Mitochondrial diseases represent a significant clinical challenge. Substantial efforts have been devoted to identifying therapeutic strategies for mitochondrial disorders, but effective interventions have remained elusive. Recently, we reported attenuation of disease in a mouse model of the human mitochondrial disease Leigh syndrome through pharmacological inhibition of the mechanistic target of rapamycin (mTOR). The human mitochondrial disorder MELAS/MIDD (Mitochondrial Encephalopathy with Lact ...[more]