Ontology highlight
ABSTRACT:
SUBMITTER: Zhao D
PROVIDER: S-EPMC6389446 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Zhao Dongdong D Meng Jian J Zhao Yingjun Y Huo Yuanhui Y Liu Yan Y Zheng Naizhen N Zhang Muxian M Gao Yue Y Chen Zhicai Z Sun Hao H Wang Xiangyu X Jing Chuya C Zhang Tongmei T Zhang Xian X Luo Hong H Wang Xin X Zhang Jie J Liu Fa-Rong FR Li Yanfang Y Bu Guojun G Wen Lei L Huang Timothy Y TY Xu Huaxi H Zhang Yun-Wu YW
Biological psychiatry 20180825 3
<h4>Background</h4>Although synaptic impairment is a prerequisite to cognitive deficiencies in Alzheimer's disease (AD), mechanisms underlying the dysregulation of essential synaptic scaffolding components and their integrity remain elusive. RPS23RG1 is a newly identified protein implicated in AD. However, the physiological function of RPS23RG1 has yet to be determined.<h4>Methods</h4>We investigated the role of RPS23RG1 in maintaining synaptic structure and function in cell cultures and in Rps2 ...[more]